AMES, Iowa (AP) — Iowa State's Scott Christopherson let loose from halfcourt with a spinning shot at the buzzer that rattled home and gave the Cyclones a 38-36 lead at the break.
The only one in the building who wasn't thrilled was coach Fred Hoiberg, who knew his team would need more than a buzzer-beater to take down No. 9 Missouri.
Hoiberg's uneasy feeling came to fruition in a frustrating second half for Iowa State.
Matt Pressey led six players in double figures with 14 points and the Tigers rallied past the Cyclones 76-69 on Wednesday night.
Christopherson had 19 points and Chris Allen scored 17 for Iowa State (12-4, 2-1), which lost for the first time in eight games.
The Cyclones' two-point halftime lead proved to be the mirage Hoiberg thought it was. They were outrebounded 38-27 on the night, hit just four 3s in the second half and went 13 of 25 from the line.
"I thought it was fool's gold," Hoiberg said of Christopherson's 3. "We could have come out of the locker room and had some momentum and corrected things. But (Missouri) made the effort plays all night."
Phil Pressey and Ricardo Ratliffe each added 12 points for the Tigers (15-1, 2-1 Big 12), who bounced back from a 75-59 loss at Kansas State by outscoring Iowa State 40-31 in the second half.
"We were mentally tough down the stretch, as far as getting stops and rebounding," Matt Pressey said. "We've really grown from that standpoint."
Royce White finished with 16 points, six rebounds and six assists. But he also had six turnovers and was just 2-of-8 shooting from the free-throw line.
The Cyclones were also outscored 40-20 in the paint by Missouri, which has just two legitimate big men in Ratliffe and Steve Moore.
"I just didn't give the right effort," White said. "It was just an effort thing."
Missouri, the Big 12's best 3-point shooting team so far, shot just 29 percent from long range in its loss to the Wildcats last weekend. The Tigers again struggled from beyond the arc, hitting just four of their first 19 attempts. But they took a slight edge early in the second half by dominating the boards and converting their opportunities from inside.
Consecutive jumpers by English and Denmon put the Tigers up 53-48 midway through the second half. Phil Pressey then drilled a crucial 3 from the corner and Michael Dixon hit an easy layup off a turnover to make it 66-58 Missouri with 4:52 to go.
"They made the effort plays all night. We executed our game plan perfectly. They make five 3s in 21 attempts. We just weren't tough enough," Hoiberg said.
White was coming off the sixth triple-double in a Big 12 game, going for 10 points, 10 assists and 18 rebounds in Saturday's 74-50 win at Texas A&M.
White was fired up from the tip, screaming in Ratliffe's face after the opening basket. But White seemed a little too amped up because he picked up two fouls in the first 5 minutes.
The Cyclones withstood White's foul trouble and poor rebounding in the first half thanks to eight 3s in 12 tries — capped by Christopherson's half-court heave at the buzzer.
"It was a nice momentum boost. It would have felt a lot better if we would have taken care of the glass," Christopherson said.
Iowa State entered play with its first 2-0 start in the Big 12 in five years, and a win would have given them a 3-0 record in the league for the first time since 2000.
Hilton Coliseum certainly anticipated a big night for the program, with a near-sellout crowd into things from the opening tip. But by letting the Tigers off the hook, the Cyclones were reminded that wins against the Big 12's elite are nearly impossible if they make as many mistakes as they did against Missouri.
"When you play a team like that, you can't afford to get outrebounded by 12 in the first half. You can't afford to let them shoot 59 percent in the second half," Christopherson said. "When it came down to money time, they executed and we didn't."
Follow Luke Meredith on Twitter @LukeMeredithAP