Cincinnati forward Kyle Washington (24) stands on the court as the Nevada team celebrates during the end of the second half of a second-round game in the NCAA college basketball tournament in Nashville, Tenn., Sunday, March 18, 2018. Nevada defeated Cincinnati 75-73. (AP Photo/Mark Humphrey)

Call them the Fallen Four.

The top four seeds in the South Region _ No. 1 Virginia, No. 2 Cincinnati, No. 3 Tennessee and No. 4 Arizona _ have all been eliminated on the opening weekend of the NCAA Tournament. It's a tourney first.

The Bearcats got booted after a memorable comeback by Nevada. The Wolf Pack rallied from 22 points down for 75-73 win. Here's another factoid from Worlock, the NCAA's stat guru.

March Madness, indeed.

Kansas State took the last spot in the Sweet 16 in the South after ending UMBC's Cinderella run with a 50-43 victory over the Retrievers.