North Carolina head coach Roy Williams, center, reacts to a play during the second half of a second-round game against Texas A&M in the NCAA men's college basketball tournament in Charlotte, N.C., Sunday, March 18, 2018. (AP Photo/Bob Leverone)

So much for home cookin' in the NCAA Tournament.

Two bracket favorites, Michigan State and defending national champion North Carolina, each lost in the second round in games played in friendly territory. 

The third-seeded Spartans were stymied in by Syracuse's zone defense in a 55-53 loss to the 11th-seeded Orange in the Midwest Region. The game was played in Detroit, about 90 miles east of Michigan State's campus in East Lansing. 

A pro-North Carolina crowd in Charlotte could't help the Tar Heels in an 86-65 loss to seventh-seeded Texas A&M in the West Region. It was the first NCAA loss for North Carolina in Charlotte after a 12-0 start there.